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Am J Surg 169(5):533538

While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

They are research-use only and not FDA-approved, so any decision to use them should follow consultation with a qualified clinician and a comprehensive plan including rest, physical therapy, and nutrition

Potent Anti-Inflammatory Action : Both peptides work together to calm local and systemic inflammation